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. 2019 Jun 20;9:211. doi: 10.3389/fcimb.2019.00211

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Copyright © 2019 Xu, Liu, Sun, An, Shang, Kong and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The drug interactions of ED and FLC (A), KCZ (B), and ICZ (C) against resistant C. albicans 24D are interpreted by the ΔE model. The 3D and contour plot were constructed by using OriginPro 7.5. The concentrations of FLC and ED are depicted on the x axis and y axis, respectively, and the ΔE values obtained for each combination is depicted on the z axis. Positive ΔE values represent synergy, and higher ΔE values suggested stronger synergistic interactions. Negative ΔE values represent antagonism.