Table 2.
Univariate and multivariate analysis of correlates of radiation-associated dysphagia.
| Characteristic | Univariate Analysis | Multivariate Analysis | |||
|---|---|---|---|---|---|
| HR (95% CI) | P-value* | HR (95%CI) | P-value* | ||
| Age (years) | Continuous | 0.296 | |||
| Smoking Status | Smoker | 1 | |||
| Never | 2.3(0.96–5.9) | 0.061 | |||
| Gender | Male | 1 | |||
| Female | 0.25(0.01–1.5) | 0.142 | |||
| Subsite | Tonsil | 1 | |||
| Base of Tongue | 1.2(0.48–3.18) | 0.667 | |||
| HPV/P16 Status | Positive | 1 | |||
| Negative | 1.1(0.05–12) | 0.935 | |||
| T Stage | 0–2 | 1 | 1 | ||
| 3–4 | 3.8(2.25–15.7) | 0.0002** | 4.56(1.46–15.31) | 0.0089** | |
| Nodal Stage | Nx-1 | 1 | |||
| N2–3 | 1.88(0.61–7) | 0.286 | |||
| Treatment Modalities | |||||
| CCRT Only | 1 | 0.0006** | 1 | 0.004** | |
| IC+CCRT | 5.6(2.6–16.46) | 6.12(2.01–20.44) | |||
| Radiotherapy alone | 0.48(0.07–2.04) | 0.72(0.06–4.82) | |||
| Radiotherapy Technique | Split | 1 | |||
| Whole Field | 1.0(0.67–4) | 0.286 | |||
| Total Radiotherapy Dose | Continuous | 0.041** | 0.696 | ||
| Number of Radiotherapy Fractions | Continuous | 0.053 | |||
| Baseline RAD, Per | No (Score 0) | 1 | 0.019** | 1 | 0.265 |
| DIGEST | |||||
| Yes (Score 1-4) | 2.0(1.197-7.36) | 1.84(0.62-5.42) | |||
*
P-values were calculated by the Chi-square test.
**
Statistically significant p-value < 0.05.
Abbreviations: CCRT; concurrent chemo/radiotherapy, IC; induction chemotherapy, RAD; radiation-associated dysphagia, DIGEST; Dynamic Imaging Grade of Swallowing Toxicity.