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Key residues in Eco RfaH. In the autoinhibited state, the NTD (gray) and CTD (α-helices; cyan) interact to bury the NTD residues that bind to the β’CH domain (orange). In the active state, the domains are connected by a (modeled) flexible linker; the NTD and the β-barrel CTD bind to RNAP and S10 respectively. In both states, the NTD can interact with the nontemplate (NT) ops DNA element (blue) and the βGL (dark magenta).
