. Author manuscript; available in PMC: 2020 Mar 18.

Published in final edited form as: Angew Chem Int Ed Engl. 2019 Feb 27;58(12):3923–3927. doi: 10.1002/anie.201814272

Table 2.

Examination of Different C-2 Substituents on the Azlactone Nucleophile^[a–c]

^[a]

Reaction conditions: 1a (0.05 mmol), 2a (3.0 equiv), Pd(PhCN)₂Cl₂ (10 mol %), PA7 (TCYP) (20 mol%), anhydrous benzene (0.1 M), 55 °C, 4 days.

^[b]

Isolated yield.

^[c]

Enantiomeric ratio determined by chiral SFC.