Table 3.
Results from M1 and M4. M1 is the joint model that shares both the random intercept and slope from the longitudinal sub-model with the random intercept from the survival model. M4 is the interval censored survival model with the longitudinal measurements as a time-varying covariate
| M1: Shared Random Effects | M4: Time Varying Covariate | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Lower | Upper | Lower | Upper | ||||||
| Parameter | Estimate | SD | 95% CrI | 95% CrI | Estimate | SD | 95% CrI | 95% CrI | |
| Linear Sub-Model | |||||||||
| b 0 | 7.24 | 0.06 | 7.12 | 7.36 | - | - | - | - | - |
| b 1 | -0.05 | 0.005 | -0.06 | -0.04 | - | - | - | - | - |
| 7.44 | 0.09 | 7.26 | 7.63 | - | - | - | - | - | |
| 1.66 | 0.14 | 1.40 | 1.94 | - | - | - | - | - | |
| 0.004 | 0.0006 | 0.003 | 0.005 | - | - | - | - | - | |
| ρ | -0.38 | 0.07 | -0.51 | -0.24 | - | - | - | - | - |
| Survival Sub-Model | |||||||||
| α | 0.57 | 0.06 | 0.47 | 0.69 | α tvc | 0.46 | 0.03 | 0.40 | 0.53 |
| Hazard | Hazard | ||||||||
| Ratio | Ratio | ||||||||
| β 0 | 0.03 | 0.01 | 0.01 | 0.06 | γ 0 | 0.17 | 0.06 | 0.08 | 0.30 |
| β1 (HLA Mismatch Number) | 1.26 | 0.07 | 1.13 | 1.40 | γ 1 | 1.29 | 0.06 | 1.17 | 1.43 |
| β2 (African American) | 2.09 | 0.56 | 1.23 | 3.39 | γ 2 | 1.79 | 0.40 | 1.11 | 2.70 |
| β3 (Hispanic) | 1.60 | 0.33 | 1.05 | 2.31 | γ 3 | 1.67 | 0.31 | 1.14 | 2.33 |
| β4 (Other Race) | 1.14 | 0.56 | 0.34 | 2.41 | γ 4 | 1.12 | 0.47 | 0.40 | 2.20 |
| β5 (30-49 years) | 0.57 | 0.15 | 0.32 | 0.93 | γ 5 | 0.67 | 0.17 | 0.42 | 1.05 |
| β6 (≥50 years) | 0.30 | 0.08 | 0.17 | 0.49 | γ 6 | 0.41 | 0.10 | 0.25 | 0.65 |
| λ 0 | 0.64 | 0.06 | 0.52 | 0.75 | η | 0.80 | 0.03 | 0.75 | 0.85 |
| λ1 (per 0.05 change) | 0.43 | 0.07 | 0.32 | 0.58 | - | - | - | - | - |
For M1, the posterior mean and 95% credible intervals are presented for the linear portion of the model, the survival portion of the model, and the association parameters. The longitudinal portion is comprised of a fixed intercept (b0), a fixed slope (b1), and a random error term (). There is also a random intercept () and a random slope for each individual (), which have a correlation parameter ρ. The survival model is comprised of fixed covariates (β), the Weibull association parameter α, and a random intercept for each individual that is related to the random intercept and slope of the longitudinal sub-model through two association parameters. The first association parameter (λ0) links the two sub-models through their shared random intercepts. The second association parameter (λ1) links the two sub-models through the longitudinal random slope and the survival random intercept. M4 contains the Weibull scale parameter, αtvc, baseline covariates with parameter γ, and the coefficient for the time-varying covariate, η