Table 1.
Liver proteins with strong DS-affinity
| a | ANA (antinuclear autoantigens) | Ref. | ||
|---|---|---|---|---|
| 10 | IPI00329998.3 | H4 | Histone H4 | [8] |
| 6 | IPI00114642.4 | Hist1h2bj | Histone H2B type 1-F/J/L | [9] |
| 5 | IPI00153400.2 | H2afj | Histone H2A.J | [9] |
| 5 | IPI00111957.3 | Hist1h2ba | Histone H2B type 1-A | [9] |
| 4 | IPI00137852.5 | H2afy | Core histone macro-H2A.1 | [10] |
| 2 | IPI00404590.1 | H1f0 | Histone H1.0 | [11] |
| 3 | IPI00119220.1 | Snrpd2 | Small nuclear ribonucleoprotein Sm D2 | [12] |
| 2 | IPI00114052.1 | Snrpb | Small nuclear ribonucleoprotein-associated protein B | [13] |
| 2 | IPI00122350.4 | Snrpa | U1 small nuclear ribonucleoprotein A | [14] |
| 2 | IPI00133955.1 | Snrpe | Small nuclear ribonucleoprotein E | [15] |
| 3 | IPI00131988.1 | Mrpl49 | 39S ribosomal protein L49, mitochondria | [16] |
| 3 | IPI00311236.1 | Rpl7 | 60S ribosomal protein L7 | [17] |
| 2 | IPI00122421.5 | Rpl27 | 60S ribosomal protein L27 | [18] |
| 2 | IPI00222549.6 | Rpl30 | 60S ribosomal protein L30 | [16] |
| 3 | IPI00124287.1 | Pabpc1 | Polyadenylate-binding protein | [19] |
| 2 | IPI00119959.1 | Banf1 | Barrier-to-autointegration factor | [20] |
| SMA (anti-smooth muscle autoantigens) / Cytoskeleton | ||||
| 6 | IPI00753793.2 | Spna2 | Isoform 2 of Spectrin alpha chain | [21] |
| 5 | IPI00123181.4 | Myh9 | Myosin-9 | [22] |
| 2 | IPI00109044.8 | G15Rik | Myosin light chain, regulatory B-like | [23] |
| 2 | IPI00354819.5 | Myl6 | Isoform Smooth muscle of Myosin light chain 6 | [24] |
| 2 | IPI00230435.1 | Lmna | Isoform C2 of Lamin-A | [25] |
| AMA (anti-mitochondrial autoantigens) | ||||
| 13 | IPI00319992.1 | Hspa5 | 78 kDa glucose-regulated protein (Grp78) | [26] |
| 13 | IPI00114209.1 | Glud1 | Glutamate dehydrogenase 1, mitochondria | [27, 28] |
| 11 | IPI00131424.3 | Cpt2 | Carnitine O-palmitoyltransferase 2, mitochondria | |
| 6 | IPI00133903.1 | Hspa9 | Stress-70 protein, mitochondria (Grp75) | [29] |
| 3 | IPI00111908.8 | Cps1 | Carbamoyl-phosphate synthase [ammonia], mitochondria | |
| 3 | IPI00273146.1 | Chdh | Choline dehydrogenase, mitochondria | |
| 2 | IPI00129577.1 | Aifm1 | Apoptosis-inducing factor 1 (Aif, Pdcd8, programmed cell death protein 8), mitochondria | [30] |
| LKM (liver-kidney microsomal autoantigens) | ||||
| 3 | IPI00111936.1 | Ugt1a9 | UDP-glucuronosyltransferase 1-9 (bilirubin-specific) | [31] |
| 3 | IPI00112322.2 | Ugt2b5 | UDP glucuronosyltransferase 2 family, polypeptide B5 | [32] |
| 2 | IPI00230113.5 | Cyb5 | Microsomal cytochrome b5 | [33] |
| 2 | IPI00131771.3 | Cox6c | Cytochrome c oxidase subunit 6c | |
| 2 | IPI00169666.3 | Ugt2b34 | UDP glucuronosyltransferase 2 family, polypeptide B3 | [32] |
| 2 | IPI00230108.6 | Pdia3 | Protein disulfide-isomerase A | [34] |
| 2 | IPI00134746.5 | Ass1 | Argininosuccinate synthase | |
| 2 | IPI00387289.3 | Ces3 | Carboxylesterase | [35] |
| Peroxisomal proteins | ||||
| 3 | IPI00112549.1 | Acsl1 | Long-chain-fatty-acid-CoA ligase | |
| 2 | IPI00312058.5 | Cat | Catalase | [36, 37] |
| 2 | IPI00223367.5 | Uox | Uricase | |
| 2 | IPI00125325.1 | Decr2 | Peroxisomal 2,4-dienoyl-CoA reductase | |
| 2 | IPI00125813.1 | Dpp4 | Dipeptidyl peptidase (CD26) | [38, 39] |
aColumns left to right: Number of peptides identified for the protein by mass spectrometry; Protein ID; Gene name; Protein name; Reference (if any) reporting autoantibodies induced by the protein