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. 2019 Jun 27;7:16. doi: 10.1186/s40478-019-0751-1

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Phosphorylated Tau immunohistochemistry (a-e) and haematoxylin and eosin staining (f) in Case1 (a-c) and Case2 (d-f). (a) pTAu staining is irregularly distributed at the sulcal depths in both neurons and glia. (b) high power view of boxed area in (a) showing perivascular accentuation of pTau staining. (c) prominent proximal dendrite staining with pTau in CA4 neurons in Case1. (d) perivascular pTAu staining in sulcal depths of Case2 (frontal cortex). (e) high power view of boxed area in (d). (f) globose fibrillary tangles in the substantia nigra with some pigment incontinence and gliosis in Case2