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. 2019 Jun 26;33:2058738419859699. doi: 10.1177/2058738419859699

Figure 4.

Figure 4.

MALAT1 inhibits apoptosis and promotes metastasis of NSCLC cells via modulating miR-200a-3p: (a) MALAT1 overexpression inhibited apoptosis of A549 cells and miR-200a-3p transfection induced apoptosis (left); knockdown of MALAT1 induced apoptosis of CAL-12T cells and miR-200a-3p inhibitors partly reversed it (right). (b) Wound healing assay showed that MALAT1 overexpression promoted motility of A549 cells and miR-200a-3p transfection partly reversed its function (left); knockdown of MALAT1 inhibited motility of CAL-12T cells and miR-200a-3p inhibitors neutralized its function (right). (c) Transwell assay showed MALAT1 overexpression promoted migration of A549 cells and miR-200a-3p transfection partly reversed its function (left); knockdown of MALAT1 inhibited migration of CAL-12T cells and miR-200a-3p inhibitors neutralized its function (right). (d) Transwell assay showed MALAT1 overexpression promoted invasion of A549 cells and miR-200a-3p transfection partly reversed its function (left); knockdown of MALAT1 inhibited invasion of CAL-12T cells and miR-200a-3p inhibitors neutralized its function (right).

*P < 0.05. **P < 0.01. ***P < 0.001.