Figure 2.

5′ to 3′ structure of the CYP2D6 locus and placement of variants. Physical position of known pharmacogenomics (PGx) variants in CYP2D6 by rsID (total N = 198). Colors indicate putative functional consequences: red = no function, blue = decreased function, purple = unknown or uncertain function, black = single-nucleotide polymorphism (SNPs) with multiple associated functional consequences [e.g., rs1135840 can be found in alleles with normal function, decreased function, and even non-functional (e.g., *35, *17, and *4, respectively)], green = no observed functional consequences to date (normal). Numbers to the right of each rsID indicate the total number of haplotypes (* alleles) on which each variant is known to be found.