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. 2019 Jun 20;10:432. doi: 10.3389/fpsyt.2019.00432

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Copyright © 2019 Jarvis, Peter and Shaman

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Consequences of CYP2D6 gene duplication for (A) the activity level of 13 expected CNV-variable (duplicated) CYP2D6 alleles with known enzyme function. Not depicted: CYP2D6 *43, which is also known to show duplications with an uncertain phenotype. (B) Individual haplotype (* allele) activity and overall metabolizer status of the “*1/*4, CNV = 4” specific patient result. Note that a copy-number of four introduces ambiguity in the reported metabolizer status due to technical uncertainty regarding which specific allele is duplicated.