Table 4.
Selection of targets identified by bio-IP with important roles in the regulation of epilepsy-relevant processes and pathwaysa
| Gene | Function | Log FC | p | FDR |
|---|---|---|---|---|
| Nr3c1 (GR) | Glucocorticoid receptor | 3.37865036 | 8.86E-16 | 2.17E-13 |
| Tsc1 | Tuberous sclerosis complex | 1.37190519 | 0.00050763 | 0.00589048 |
| Nrp1 | AG, MFS | 1.3675057 | 7.45E-06 | 0.00017204 |
| Tgfbr1 | TGFβ signaling | 1.35700473 | 1.27E-06 | 3.73E-05 |
| Mtss1 | Spine density | 1.3275843 | 0.00238517 | 0.02018217 |
| PlxnA4 | AG, MFS | 1.20703562 | 0.00012557 | 0.00190651 |
| Cacna1c | Calcium channel | 1.1901732 | 0.00076192 | 0.00819715 |
| Ncam1 | Neurite outgrowth | 1.05245567 | 5.18E-05 | 0.00092656 |
| Slit2 | AG, MFS | 1.04442804 | 0.00033258 | 0.00418342 |
| Mef2a | Spine density | 0.983455 | 0.00203267 | 0.01769962 |
| Creb1 | Transcription factor | 0.90909684 | 0.00363345 | 0.02809798 |
aThese targets were selected based on their function involved in key neuronal functions. AG, Axon guidance; MFS, mossy fiber sprouting.