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. 2019 Jun 26;39(26):5210–5221. doi: 10.1523/JNEUROSCI.2723-18.2019

Figure 2.

Figure 2.

Increased dendritic but not somatic inhibition in Ts65Dn mice. A, Left, Experimental design. Axon collaterals of local interneurons targeting the dendritic compartment were stimulated in in SR. IPSCs evoked at increasing stimulation strength were recorded at 0 mV. Right, Representative mean IPSCs recorded from pyramidal neurons in Ts65Dn and WT mice. B, The same for local stimulation of interneuron axon collaterals targeting the perisomatic compartment in stratum pyramidale (SP). C, Input–output relationship of IPSC amplitude evoked in SR versus stimulating current strength. A two-way ANOVA revealed a significant genotype × stimulation intensity interaction (*p < 0.0001, F(3,72) = 8.316). Statistically significant differences between neurons from Ts65Dn (n = 12) and WT mice (n = 14) are indicated for specific stimulation current intensities (p < 0.05; Sidak's multiple-comparisons test). D, Input–output relationship of IPSC amplitude evoked in SP versus stimulating current strength (WT, n = 14; Ts65Dn, n = 9).