Table 1.
Cellular properties of CA1 pyramidal neurons in Ts65Dn mice and WT littermatesa
| Ts65Dn (n = 27) | WT (n = 25) | |
|---|---|---|
| Response to current steps | ||
| Membrane potential (mV) | −67.7 ± 3.0 | −67.2 ± 1.9 |
| Capacitance (pF) | 231.0 ± 19.3 | 241.4 ± 12.5 |
| Input resistance (mΩ) | 95.2 ± 20.0 | 90.3 ± 22.6 |
| τmembrane (ms) | 20.9 ± 7.3 | 21.4 ± 6.5 |
| IH dependent sag (mV) | 2.3 ± 0.5 | 2.4 ± 0.8 |
| Rheobase current (pA) | 154.6 ± 45.0 | 168.0 ± 53.8 |
| Spike waveform | ||
| Firing threshold (mV) | −41.8 ± 2.5 | −41.1 ± 2.0 |
| Amplitude (mV) | 88.5 ± 8.7 | 88.4 ± 9.0 |
| Half-width (ms) | 0.83 ± 0.12 | 0.82 ± 0.12 |
aData are mean ± SD.