Figure 10.

Enhanced acoustic startle, but normal prepulse inhibition and susceptibility to induced seizure, in Lrfn2^−/− mice. A, Enhanced acoustic startle responses of Lrfn2^−/− mice (4–5 months) in a high loudness range (>110 dB). n = 20 mice for WT and 24 mice for KO. **p < 0.01, ***p < 0.001, repeated-measures two-way ANOVA with Bonferroni test. B, Normal prepulse inhibition in Lrfn2^−/− mice (4–5 months). n = 14 mice for WT and 17 mice for KO. Repeated-measures two-way ANOVA. C, Normal susceptibility to a seizure induced by PTZ (40 mg/kg, i.p.) in Lrfn2^−/− mice (5–6 months). The numbers in pie charts indicate the proportions of mice that reached the indicated stages of seizure at the end of the test (10 min). n = 13 mice for WT and 16 mice for KO. NS, χ² analysis.