Normal learning and memory in Lrfn2−/− mice. A, Normal novel object recognition memory in Lrfn2−/− mice (2–3 months). n = 17 mice for WT and 18 mice for KO. NS, Student's t test. B, Normal displaced object recognition memory in Lrfn2−/− mice (2–3 months). n = 16 mice for WT and KO. NS, Student's t test. C–H, Normal learning and memory in Lrfn2−/− mice (3–4 months) in the learning, probe, and reversal phases of the Morris water maze test. Pre-T, Previous target. n = 9 mice for WT and 10 mice for KO. *p < 0.05, NS, repeated-measures two-way ANOVA, Student's t test, and Mann–Whitney U test. I–K, Normal fear learning and memory in Lrfn2−/− mice (4–5 months). Mice with acquired fear memory in a spatial context combined with a sound cue (I) were tested for contextual fear memory 24 h after training (J) and for cued fear memory 28 h after training (K). n = 14 mice for WT and 17 mice for KO. NS, repeated-measures two-way ANOVA, Student's t test, and Mann–Whitney U test.