Table 1.
Level of expression of early transcription factor in S63del nerves at different time points after birth
| Gene | 5 d | 28 d | 4 mo |
|---|---|---|---|
| Sox2 | 1.6 | 2.9 | 1.6 |
| Id2 | 1.75 | 2 | 1.75 |
| C-Jun | 1.4 | 1.6 | 1.2 |
| Sox4 | 1.2 | 2 | 1.3 |
| Oct6/Pou3f1 | 1.2 | 2.9 | 2 |
| Krox20 | 1 | 1.3 | 1.3 |
| Scap | −1.5 | −1.5 | −1.3 |
| Srebf2 | −1.55 | −1.4 | −1.5 |
Microarray analysis of S63del nerves shows sustained expression of dedifferentiation genes. Expression levels are expressed as fold change compared with WT control of early Schwann cell transcription factors in S63del sciatic nerves at 5 d, 28 d, and 4 months after birth (D'Antonio et al., 2013).