Figure 4.

In vivo efficacy of the glutathione-dependent metabolic activity of the blood–CSF barrier toward CDNB. Levels of CDNB were measured in the CSF sampled from control animals (black) and animals depleted in choroidal GSH (BSO treated, gray) in P3 rats perfused with 200 or 500 μm CDNB. Data are expressed as the mean ± SEM, (n). **p < 0.01, statistically different from control animals, one-tailed Student's t test for unequal variance. Insert shows no changes in CDNB concentration measured in the outflow perfusate collected from the cardiac atrium between control and BSO-treated animals (mean ± SEM, no statistical difference).