Figure 5.

Conditional deletion of p53 from neural progenitor cells leads to forgetting of recent, but not remote, contextual fear memories. a, iKO-p53 and control WT mice were trained in contextual fear conditioning and treated with TAM 1 d (immediate condition) or 28 d (delay condition) later. Contextual fear memory was assessed 28 d after TAM treatment. b, Representative images showing that showed increased number of DCX⁺ cells in DG in an iKO-p53 mouse compared with a control WT mouse. Scale bar, 50 μm. c, iKO-p53 mice showed increased number of DCX⁺ cells in DG compared with WT mice. d, Conditional deletion of p53 reduced levels of freezing in the immediate, but not delay, condition. **p < 0.01.