Table 1.
Summary table of passive membrane properties determined in current-clamp recordings from principal neurons in slices of the BLA from different experimental groups of mice
| Group | Veh_Veh | Poly I:C_Veh | Veh_LPS | Poly I:C_LPS | Poly I:C | LPS |
|---|---|---|---|---|---|---|
| No. cells/no. mice | 21/10 | 24/11 | 15/7 | 20/12 | ||
| Rseries (MΩ) | 17.2 ± 0.7 | 16.5 ± 0.6 | 17.1 ± 1.0 | 17.5 ± 0.8 | F(1,76) = 0.03 (p = 0.871) | F(1,76) = 0.29 (p = 0.59) |
| Rinput (MΩ) | 159.3 ± 12.5 | 155.4 ± 16.4 | 152.0 ± 14.5 | 131.0 ± 12.8 | F(1,76) = 0.71 (p = 0.402) | F(1,76) = 1.16 (p = 0.285) |
| RMP (mV) | 74.2 ± 0.9 | 76.1 ± 1.1 | 76.6 ± 1.6 | 72.5 ± 1.1 | F(1,76) = 0.87 (p = 0.355) | F(1,76) = 0.26 (p = 0.61) |
| τmembrane (ms) | 2.7 ± 0.1 | 3.1 ± 0.1 | 3.0 ± 0.1 | 2.9 ± 0.1 | F(1,76) = 1.05 (p = 0.308) | F(1,76) = 0.41 (p = 0.526) |
| Cm (pF) | 181.8 ± 9.1 | 215.3 ± 12.1 | 204.1 ± 11.8 | 196.3 ± 7.4 | F(1,76) = 1.48 (p = 0.228) | F(1,76) = 0.02 (p = 0.877) |
The membrane capacitance (Cm) was calculated using the following equation: Cm = τ(1/Ra + 1/Rin), as described previously (Gentet et al., 2000). Two-way ANOVA in a 2 × 2 factorial design was used to evaluate the statistical significance of differences between experimental groups.