Figure 3.

Treatment with TDP6 increased TrkB phosphorylation in the remyelinating corpus callosum. A, Representative micrographs of pTrkB^S478 immunostaining in the caudal region of the corpus callosum. Scale bar, 20 μm. Asterisk, PDGFRα⁺ cell featured in inset; arrowhead, CC1⁺ cell featured in inset. B, Proportion of pTrkB^S478+ cells in the caudal corpus callosum was increased with TDP6 treatment compared with BDNF and vehicle controls (**p = 0.0047). C, Proportion of pTrkB^S478+ cells that were PDGFRα⁺ OPCs tended toward an increase with TDP6 treatment (p = 0.12). D, Proportion of pTrkB^S478+ cells that were CC1⁺ oligodendrocytes significantly increased with both BDNF and TDP6 treatment. B–D, n = 7–9/group, one-way ANOVA with Tukey's post hoc multiple comparisons. Mean ± SEM plotted.