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. 2018 Jul 11;38(28):6310–6322. doi: 10.1523/JNEUROSCI.0658-18.2018

Figure 6.

Figure 6.

Effects on LH secretion of optogenetic activation of RP3VKISSand RP3VGABA neurons in vivo. A, Activation of RP3VKISS neurons at 10 Hz for 15 min increases LH secretion in AAV-injected Kiss1-IRES-Cre mice (n = 5) but not wild-type controls (n = 5). Symbols in red show time points significantly different to prestimulation values (repeated-measures ANOVA with post hoc Dunnett's; see results for exact p values). B, Activation of RP3VKISS neurons at 10 Hz for 30 min using either a bursting (n = 4) or continuous (n = 5) stimulation pattern significantly increases LH secretion in AAV-injected Kiss1-IRES-Cre mice. C, Activation of RP3VGABA neurons at 2 Hz for 15 min has no significant effect on LH secretion in AAV-injected Vgat-Cre mice (n = 8) or controls (n = 4). D, Activation of RP3VGABA neurons at 10 Hz for 15 min significantly increases LH secretion in AAV-injected Vgat-Cre mice (n = 7) but not controls (n = 6). Symbols in red show time points significantly different to prestimulation values (repeated-measures ANOVA with post hoc Dunnett's tests; see results for exact p values).