Figure 6.

IP6K2-KO mice show deficiencies in motor coordination and locomotor activity. A, Motor learning and coordination were compared between the IP6K2-KO and WT mice by the rotarod test. This test revealed reduced motor learning and coordination in the IP6K2-KO mice compared with WT mice. B, General locomotor activity in IP6K2-KO mice was assessed by the open field analysis. Such behavioral analysis also revealed reduced peripheral as well as central activity in IP6K2-KO mice when compared with WT mice. C, Gait analysis in IP6K2-KO mice also showed significant decreases in stride length and average speed of movement with respect to WT mice. However, there was no significant change between the paw print width of the WT and K2-KO mice. Data shown are representative of three independent experiments done under identical conditions with the mean ± SD: ***p < 0.001, **p < 0.01.