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. 2018 Sep 12;38(37):8060–8070. doi: 10.1523/JNEUROSCI.0444-18.2018

Figure 4.

Figure 4.

Time window of synaptic tagging in the ACC. A, Top, Schematic diagram of the recording procedure. We applied the weak TBS protocol to the S2 site at 1 h after strong TBS of the S1 site (tagged TBS, 1 h). Bottom, Pooled data showed that both strong TBS at S1 site and weak TBS at S2 site could induce L-LTP (n = 5 slices/5 mice). B, Top, schematic diagram of the recording procedure. The weak TBS protocol was applied to the S2 site at 2 h after strong TBS of the S1 site (tagged TBS, 2 h). Bottom, Pooled data showed that weak TBS could still benefit from the strong TBS by inducing sustained L-LTP (n = 6 slices/6 mice). C, Bar histogram summarizing quantified data within last 10 min of the L-LTP recording for strong TBS, tagged TBS 30 min, tagged TBS 1 h, and tagged TBS 2 h. NS, No significance. D, Percentage of L-LTP-showing channels among the four groups. Although L-LTP could still be generally induced by weak TBS, the percentage of channels that undergo L-LTP was clearly decreased with 2 h interval. *p < 0.05 versus strong TBS. NS, No significance. Large arrows in A and B indicate starting point of strong TBS application; small arrows mark the time point of weak TBS delivery. Error bars represent SEM.