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. 2018 Jul 4;38(27):6130–6144. doi: 10.1523/JNEUROSCI.3238-17.2018

Figure 2.

Figure 2.

Expression of PNNs in the mouse DCN. A, Expression of CSPGs in the developing mouse cerebellum. Cat-301 is an antibody against aggrecan, one of the primary CSPGs. Bottom, High-magnification images of the DCN in the top. Red, Cat-301; green, GFP of GAD67+/GFP mouse. B, Large DCN neuron expresses CSPGs. Red, Cat-301; green, GFP of GAD67+/GFP mouse. C, ChABC decreased PNNs labeled by WFA. Mouse cerebellar acute slices with (right) and without (left) 4 h treatment of ChABC (0.25 U/ml). D, Intensity of WFA staining in the slices treated with ChABC for 4 h normalized to the average intensity of control slices. *p < 0.05 using unpaired Student's t test.