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. 2018 Nov 21;38(47):10220–10235. doi: 10.1523/JNEUROSCI.1590-18.2018

Figure 6.

Figure 6.

Epileptic seizure and kindling evoked by treating mice with PTZ. A, Seizure scores in 7-week-old WT (white bars) and CS/CS (black bars) mice received a single injection of PTZ at a dose of 0, 20, 30, 40, 60, or 80 mg/kg. Six white bars [WT]: n = 21, 12, 10, 13, 18, 16, six black bars [CS/CS]: n = 17, 13, 12, 15, 16, 16 (left to right). B, Seizure scores in 13-week-old WT (white bars) and CS/CS (black bars) mice received a single injection of PTZ at a dose of 0, 20, 40, or 60 mg/kg. Four white bars [WT]: n = 16, 13, 14, 14, four black bars [CS/CS]: n = 13, 14, 17, 16 (left to right). C, Occurrence of generalized tonic-clonic seizures (stage 4 and 5) in 7-week-old WT (white bars) and CS/CS (black bars) mice that received a single injection of PTZ at a dose of 40 (right, n = 13, 15, respectively) or 60 (left, n = 17, 16, respectively) mg/kg. D, Occurrence of generalized tonic-clonic seizures (stage 4 and 5) in 13-week-old WT (white bars) and CS/CS (black bars) mice that received a single injection of PTZ at a dose of 40 (right, n = 12, 12, respectively) or 60 (left, n = 13, 13, respectively) mg/kg. E, Kindling evoked by treating mice repeatedly with PTZ. WT (white) and CS/CS (black) mice were administered PTZ 12 times at a dose of 30 mg/kg (squares, n = 8, respectively) or saline (PBS, circles, n = 5, respectively) from 7-week-old (genotype effect, F(1,14) = 8.571, p = 0.011; kindling effect, F(11,154) = 24.06, p < 0.0001). F, Injection times of PTZ to induce the initial generalized tonic-clonic seizures (n = 8, respectively). G, Injection times of PTZ to establish the kindling response (n = 8, respectively). H, Continuous kindling response (n = 8, respectively). Error bars indicate SEM. *p < 0.05, **p < 0.01. See also Extended Figure 6-1.