Figure 7.

Nav1.7 cKO mice are sensitive to some noxious stimuli and time course of behavioral effects. A, von Frey test of mechanical threshold. Tamoxifen treatment did not change the response of Nav1.7 cKO mice to von Frey filaments. Cutoff = 7.5 g. B, Intensity-response relationship to electrical stimuli delivered through a floor grid did not differ between genotypes. C, Nav1.7 cKO mice learn an active avoidance paradigm where electrical stimuli are an effective aversive teaching signal in a manner indistinguishable from control mice. n = 24 control, 18 cKO mice. D–F, Time courses to develop insensitivity to the hot plate test (D), the tail immersion test (E), and the Hargreaves test (F) when measured at weekly intervals following tamoxifen dosing. Statistical analysis described in Table 1. Error bars indicate SEM.