Table 1. MIC (minimum inhibitory concentrations) of fluoroquinolone derivatives.
| Species | Strain | MIC (μg mL–1) |
|||
| Ciprofloxacin 1 | Cipro-N3 2 | Cipro-NBD 3 | Cipro-DMACA 4 | ||
| Staphylococcus aureus | ATCC 25923 | 0.125–0.5 | 0.25 | 32–≥64 | 16 |
| Bacillus subtillis | ATCC 6051 | 0.313–0.06 | 0.06–0.25 | 8 | 4 |
| Enterococcus faecium | ATCC 35667 | 1–8 | 16–≥64 | 32 | 32–≥64 |
| Klebsiella pneumoniae | ATCC 13883 | 0.015–0.06 | 0.125–0.25 | 8–16 | 4–32 |
| Acinetobacter baumannii | ATCC 19606 | 0.5–1 | 0.25–0.5 | 32–≥64 | 32 |
| Pseudomonas aeruginosa | ATCC 27853 | 0.25–1 | 8–≥64 | 32–≥64 | 32–≥64 |
| PAO750 PAO397 Δ a | ≤0.25 | 32–≥64 | 4 | 2–8 | |
| Escherichia coli | ATCC 25922 | ≤0.004 | 0.06–0.25 | 8 | 2 |
| MB4902 ΔlpxC | ≤0.004 | 0.25–1 | 1–4 | 2 | |
| MB5747 ΔtolC | ≤0.004 | 0.25–1 | 0.125–0.25 | 0.5–1 | |
| MB5746 ΔlpxC, ΔtolC | ≤0.004 | 0.25–1 | 0.06–0.125 | 0.5–1 | |
aDelta efflux pump mutant: ΔmexAB-oprM, ΔmexCD-oprJ, ΔmexEF-oprN, ΔmexJKL, ΔmexXY, ΔopmH, ΔpscC.