Table 1. Minimum pharmacophore determination. Compounds were tested for activity against M. tuberculosis (MBC_4.5) and HepG2 cells (IC₅₀). MBC_4.5 are reported as the median. HepG2 IC₅₀ are reported as the mean ± standard deviation. The number of replicates is in parentheses.

Cpd	ID	R1	R2	MBC4.5 (μM)	HepG2 IC50 (μM)
1	IDR-0019306	2,4-Cl–Ph–NH-	4-Br–Ph–SO2-	6.3 (5)	6.2 ± 1.1 (3)
3	IDR-0597329	4-Cl–Ph–NH-	4-Br–Ph–SO2-	50 (2)	11 ± 4.7 (2)
4	IDR-0484542	PhNH-	4-Br–Ph–SO2-	100 (2)	30 ± 3.5 (2)
5	IDR-0597554	EtNH-	4-Br–Ph–SO2-	>200 (3)	>100 (3)
6	IDR-0597555	H2N-	4-Br–Ph–SO2-	>200 (3)	>100 (3)
7	IDR-0596462	2,4-Cl–Ph–NH-	Ph–SO2-	>200 (4)	19 ± 9.2 (2)
8	IDR-0596461	2,4-Cl–Ph–NH-	Me–SO2-	75 (2)	78 ± 29 (2)
9	IDR-0597928	2,4-Cl–Ph–NH-	H-	200 (4)	40 ± 2.3 (3)