Table 3. 2,4-Dichloroaniline substitutions. Compounds were tested for activity against M. tuberculosis (MBC_4.5) and HepG2 cells (IC₅₀). MBC_4.5 are reported as the median. HepG2 IC₅₀ are reported as the mean ± standard deviation. The number of replicates is in parentheses.

Cpd	ID	R1	MBC4.5 (μM)	HepG2 IC50 (μM)
16	IDR-0600849	BuNH-	100 (4)	59 ± 0.71 (2)
17	IDR-0597328	Cyclopropyl-NH-	>200 (2)	>100 (2)
18	IDR-0600848	Propargyl-NH-	>200 (5)	83 ± 12 (2)
19	IDR-0600851	Cycloheptyl-NH-	>200 (5)	24 ± 6.4 (2)
20	IDR-0600850	2-Adamantyl-NH-	>200 (4)	20 ± 4.2 (2)
21	IDR-0600833	Piperidyl-	>200 (2)	>100 (5)
22	IDR-0600834	Morpholinyl-	>200 (2)	>100 (5)
23	IDR-0600866	4-Me-Piperazinyl-	>200 (4)	>100 (2)
24	IDR-0597331	2-Pyridyl-NH-	113 (6)	52 ± 13 (2)
25	IDR-0597270	2,4-Cl–Ph–NMe-	>200 (2)	60 ± 9.9 (2)