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P2ry12 mRNA expression correlates with diabetes-related impairments and rescue of microglial process chemotaxis. Graphs represent normalized (to β-actin) Ifngr1, Ifngr2, or P2ry12 receptor expression mRNA expression in somatosensory cortex. P2ry12, but not Ifngr1, Ifngr2 mRNA expression, was significantly reduced in untreated diabetic mice, which could be reversed with DEX treatment or IFN-γ-blocking antibodies. *p < 0.05 nondiabetic versus untreated diabetic mice.
