. 2018 Jan 24;38(4):937–961. doi: 10.1523/JNEUROSCI.1906-17.2017

Table 7.

Reaction parameters used in the models

Reaction	k_on (M⁻¹ s⁻¹)	k-_off (s⁻¹)	α (s⁻¹)
DARPP-32 + CdK5 → DARPP-32 - CdK5	5.6e + 06	12
DARPP-32 - CdK5 → DARPP-32^T75 + CdK5		3
DARPP-32 + CK1 → DARPP-32 - CK1	4.4e + 06	12
DARPP-32 - CK1 → DARPP-32^S130 + CK1		3
DARPP-32 + PKA → DARPP-32 - PKA	5.6e + 06	10.8
DARPP-32 - PKA → DARPP-32^T34 + PKA		2.7
DARPP-32^T34 + CdK5 → DARPP-32^T34 - CdK5	5.6e + 06	12
DARPP-32^T34 - CdK5 → DARPP-32^T34,T75 + CdK5		3
DARPP-32^T34 + CK1 → DARPP-32^T34 - CK1	4.4e + 06	12
DARPP-32^T34 - CK1 → DARPP-32^T34,S130 + CK1		3
DARPP-32^T34 + PP2B → DARPP-32^T34 - PP2B	1e + 08	16
DARPP-32^T34 - PP2B → DARPP-32 + PP2B		4
DARPP-32^T75 + CK1 → DARPP-32^T75 - CK1	4.4e + 06	12
DARPP-32^T75 - CK1 → DARPP-32^T75,S130 + CK1		3
DARPP-32^T75 + PKA → DARPP-32^T75 - PKA	5.6e + 06	10.8
DARPP-32^T75 - PKA → DARPP-32^T34,T75 + PKA		0
DARPP-32^T75 + PP2A → DARPP-32^T75 - PP2A	3.8e + 06	24
DARPP-32^T75 - PP2A → DARPP-32 + PP2A		10
DARPP-32^T75 + PP2AP → DARPP-32^T75 - PP2AP	1.7e + 07	24
DARPP-32^T75 - PP2AP → DARPP-32^T75 + PP2AP		40
DARPP-32^S130 + CdK5 → DARPP-32^S130 - CdK5	5.6e + 06	12
DARPP-32^S130 - CdK5 → DARPP-32^T75,S130 + CdK5		3
DARPP-32^S130 + PKA → DARPP-32^S130 - PKA	5.6e + 06	10.8
DARPP-32^S130 - PKA → DARPP-32^T34,S130 + PKA		2.7
DARPP-32^S130 + PP2C → DARPP-32^S130 - PP2C	7.5e + 06	12
DARPP-32^S130 - PP2C → DARPP-32 + PP2C		3
DARPP-32^T34,T75 + CK1 → DARPP-32^T34,T75 - CK1	4.4e + 06	12
DARPP-32^T34,T75 - CK1 → DARPP-32^T34,T75,S130 + CK1		3
DARPP-32^T34,T75 + PP2A → DARPP-32^T34,T75 - PP2A	3.8e + 06	24
DARPP-32^T34,T75 - PP2A → DARPP-32^T34 + PP2A		10
DARPP-32^T34,T75 + PP2AP → DARPP-32^T34,T75 - PP2AP	1.7e + 07	40
DARPP-32^T34,T75 - PP2AP → DARPP-32^T34 + PP2AP		24
DARPP-32^T34,T75 + PP2B → DARPP-32^T34,T75 - PP2B	1e + 08	1,600
DARPP-32^T34,T75 - PP2B → DARPP-32^T75 + PP2B		4
DARPP-32^T34,S130 + CdK5 → DARPP-32^T34,S130 - CdK5	5.6e + 06	12
DARPP-32^T34,S130 - CdK5 → DARPP-32^T34,T75,S130 + CdK5		3
DARPP-32^T34,S130 + PP2B → DARPP-32^T34,S130 - PP2B	7.5e + 04	0.12
DARPP-32^T34,S130 - PP2B → DARPP-32^S130 + PP2B		0.03
DARPP-32^T34,S130 + PP2C → DARPP-32^T34,S130 - PP2C	7.5e + 06	12
DARPP-32^T34,S130 - PP2C → DARPP-32^T34 + PP2C		3
DARPP-32^T75,S130 + PKA → DARPP-32^T75,S130 - PKA	5.6e + 06	10.8
DARPP-32^T75,S130 - PKA → DARPP-32^T34,T75,S130 + PKA		0
DARPP-32^T75,S130 + PP2A → DARPP-32^T75,S130 - PP2A	3.8e + 06	24
DARPP-32^T75,S130 - PP2A → DARPP-32^S130 + PP2A		10
DARPP-32^T75,S130 + PP2AP → DARPP-32^T75,S130 - PP2AP	1.7e + 07	40
DARPP-32^T75,S130 - PP2AP → DARPP-32^S130 + PP2AP		24
DARPP-32^T75,S130 + PP2C → DARPP-32^T75,S130 - PP2C	7.5e + 06	12
DARPP-32^T75,S130 - PP2C → DARPP-32^T75 + PP2C		3
DARPP-32^T34,T75,S130 + PP2A → DARPP-32^T34,T75,S130 - PP2A	3.8e + 06	24
DARPP-32^T34,T75,S130 - PP2A → DARPP-32^T34,S130 + PP2A		10
DARPP-32^T34,T75,S130 + PP2AP → DARPP-32^T34,T75,S130 - PP2AP	1.7e + 07	40
DARPP-32^T34,T75,S130 - PP2AP → DARPP-32^T34,S130 + PP2AP		24
DARPP-32^T34,T75,S130 + PP2B → DARPP-32^T34,T75,S130 - PP2B	7.5e + 04	120
DARPP-32^T34,T75,S130 - PP2B → DARPP-32^T75,S130 + PP2B		0.03
DARPP-32^T34,T75 + PP2C → DARPP-32^T34,T75,S130 - PP2C	7.5e + 06	3
DARPP-32^T34,T75,S130 - PP2C → DARPP-32^T34,T75,S130 + PP2C		12
CK1P + PP2B → CK1P - PP2B	3e + 08	24
CK1P - PP2B → CK1 + PP2B		6
CK1 → CK1P			1
PDE + PKA → PDE - PKA	6e + 06	36
PDE - PKA → PDEP + PKA		9
PDEP → PDE			0.1
PP2A + PKA → PP2A - PKA	1e + 08	16
PP2A - PKA → PP2AP + PKA		4
PP2AP → PP2A			5
PP2B (inactive) + Ca²⁺ → PP2B (inactive) - Ca²⁺	1e + 15	1
PP2B (inactive) - Ca²⁺ + Ca²⁺ → PP2B	3e + 15	1
R2C2 + cAMP → cAMP - R2C2	5.4e + 07	33
cAMP - R2C2 + cAMP → cAMP2 - R2C2	5.4e + 07	33
cAMP2 - R2C2 + cAMP → cAMP3 - R2C2	7.5e + 07	110
cAMP3 - R2C2 + cAMP → cAMP4 - R2C2	7.5e + 07	32.5
cAMP4-R2C + PKA → cAMP4 - R2C2	1.8e + 07	60
cAMP4-R2 + PKA → cAMP4 - R2C	1.8e + 07	60
cAMP + PDE → cAMP - PDE	2.52e + 06	40
cAMP-PDE → AMP + PDE		10
cAMP + PDEP → cAMP -PDEP	5.04e + 06	80
cAMP-PDEP → AMP + PDEP		20
Ca²⁺ → NULL			0.6
Ca²⁺ + CK2 → CK2-Ca²⁺	1e + 15	3e + 15
CK2-Ca²⁺ + DARPP-32 → DARPP-32 - CK2 - Ca²⁺	4.4e5	12
DARPP-32-CK2-Ca²⁺ → DARPP-32^S97 + CK2 - Ca²⁺		3
DARPP-32^S97 + PP2A → DARPP-32^S97 - PP2A	3.8e + 06	24
DARPP-32^S97 - PP2A → DARPP-32 + PP2A		10
DARPP-32^T34,S97 + PP2A → DARPP-32^T34,S97 - PP2A	3.8e + 06	24
DARPP-32^T34,S97 - PP2A → DARPP-32^T34 + PP2A		10
DARPP-32^T34,S97 - PP2A → DARPP-32^S97 + PP2A		10
DARPP-32^T75,S97 + PP2A → DARPP-32^T75,S97 - PP2A	3.8e + 06	24
DARPP-32^T75,S97 - PP2A → DARPP-32^T75 + PP2A		10
DARPP-32^T75,S97 - PP2A → DARPP-32^S97 + PP2A		10
DARPP-32^S97,S130 + PP2A → DARPP-32^S97,S130 - PP2A	3.8e + 06	24
DARPP-32^S97,S130 - PP2A → DARPP-32^S130 + PP2A		10
DARPP-32^S97,S130 - PP2A → DARPP-32^S97 + PP2A		10
DARPP-32^T34,T75,S97 + PP2A → DARPP-32^T34,T75,S97 - PP2A	3.8e + 06	24
DARPP-32^T34,T75,S97 - PP2A → DARPP-32^T75,S97 + PP2A		10
DARPP-32^T34,T75,S97 - PP2A → DARPP-32^T34,S97 + PP2A		10
DARPP-32^T34,T75,S97 - PP2A → DARPP-32^T34,T75 + PP2A		10
DARPP-32^T75,S97,S130 + PP2A → DARPP-32^T75,S97,S130 - PP2A	3.8e + 06	24
DARPP-32^T75,S97,S130 - PP2A → DARPP-32^S97,S130 + PP2A		10
DARPP-32^T75,S97,S130 - PP2A → DARPP-32^T75,S130 + PP2A		10
DARPP-32^T75,S97,S130 - PP2A → DARPP-32^T75,S97 + PP2A		10
DARPP-32^T34,S97,S130 + PP2A → DARPP-32^T34,S97,S130 - PP2A	3.8e + 06	24
DARPP-32^T34,S97,S130 - PP2A → DARPP-32^S97,S130 + PP2A		10
DARPP-32^T34,S97,S130 - PP2A → DARPP-32^T34,S130 + PP2A		10
DARPP-32^T34,S97,S130 - PP2A → DARPP-32^T34,S97 + PP2A		10
DARPP-32^T34,T75,S130 + PP2A → DARPP-32^T34,T75,S130 - PP2A	3.8e + 06	24
DARPP-32^T34,T75,S130 - PP2A → DARPP-32^T75,S130 + PP2A		10
DARPP-32^T34,T75,S130 - PP2A → DARPP-32^T34,S130 + PP2A		10
DARPP-32^T34,T75,S130 - PP2A → DARPP-32^T34,T75 + PP2A		10
DARPP-32^{T34,T75,S97,S130} + PP2A → DARPP-32^{T34,T75,S97,S130} - PP2A	3.8e + 06	24
DARPP-32^{T34,T75,S97,S130} - PP2A → DARPP-32^T75,S97,S130 + PP2A		10
DARPP-32^{T34,T75,S97,S130} - PP2A → DARPP-32^T34,S97,S130 + PP2A		10
DARPP-32^{T34,T75,S97,S130} - PP2A → DARPP-32^T34,T75,S130 + PP2A		10
DARPP-32^{T34,T75,S97,S130} - PP2A → DARPP-32^T34,T75 + PP2A		10
DARPP-32^S97 + CdK5 → DARPP-32^S97 - CdK5	5.6e + 06	12
DARPP-32^S97 - CdK5 → DARPP-32^T75,S97 + CdK5		3
DARPP-32^T34,S97 + CdK5 → DARPP-32^T34,S97 - CdK5	5.6e + 06	12
DARPP-32^T34,S97 - CdK5 → DARPP-32^T34,T75,S97 + CdK5		3
DARPP-32^S97,S130 + CdK5 → DARPP-32^S97,S130 - CdK5	5.6e + 06	12
DARPP-32^S97,S130 - CdK5 → DARPP-32^T75,S97,S130 + CdK5		3
DARPP-32^T34,S97,S130 + CdK5 → DARPP-32^T34,S97,S130 - CdK5	5.6e + 06	12
DARPP-32^T34,S97,S130 - CdK5 → DARPP-32^{T34,T75,S97,S130} + CdK5		3
DARPP-32^S97 + CK1 → DARPP-32^S97 - CK1	4.4e + 06	12
DARPP-32^S97 - CK1 → DARPP-32^S97,S130 + CK1		3
DARPP-32^T34,S97 + CK1 → DARPP-32^T34,S97 - CK1	4.4e + 06	12
DARPP-32^T34,S97 - CK1 → DARPP-32^T34,S97,S130 + CK1		3
DARPP-32^T75,S97 + CK1 → DARPP-32^T75,S97 - CK1	4.4e + 06	12
DARPP-32^T75,S97 - CK1 → DARPP-32^T75,S97,S130 + CK1		3
DARPP-32^T34,T75,S97 + CK1 → DARPP-32^T34,T75,S97 - CK1	4.4e + 06	12
DARPP-32^T34,T75,S97 - CK1 → DARPP-32^{T34,T75,S97,S130} + CK1		3
DARPP-32^T34,S97 + PP2B → DARPP-32^T34,S97 - PP2B	7.5e + 04	120
DARPP-32^T34,S97 - PP2B → DARPP-32^S97 + PP2B		0.03
DARPP-32^T34,T75,S97 + PP2B → DARPP-32^T34,T75,S97 - PP2B	7.5e + 04	120
DARPP-32^T34,T75,S97 - PP2B → DARPP-32^T75,S97 + PP2B		0.03
DARPP-32^T34,S97,S130 + PP2B → DARPP-32^T34,S97,S130 - PP2B	7.5e + 04	120
DARPP-32^T34,S97,S130 - PP2B → DARPP-32^S97,S130 + PP2B		0.03
DARPP-32^T34,T75,S130 + PP2B → DARPP-32^T34,T75,S130 - PP2B	7.5e + 04	120
DARPP-32^T34,T75,S130 - PP2B → DARPP-32^T75,S130 + PP2B		0.03
DARPP-32^{T34,T75,S97,S130} + PP2B → DARPP-32^{T34,T75,S97,S130} - PP2B	7.5e + 04	120
DARPP-32^{T34,T75,S97,S130} - PP2B → DARPP-32^T75,S97,S130 + PP2B		0.03
DARPP-32^S97,S130 + PP2C → DARPP-32^S97,S130 - PP2C	7.5e + 06	12
DARPP-32^S97,S130 - PP2C → DARPP-32^S97 + PP2C		3
DARPP-32^T34,S97,S130 + PP2C → DARPP-32^T34,S97,S130 - PP2C	7.5e + 06	12
DARPP-32^T34,S97,S130 - PP2C → DARPP-32^T34,S97 + PP2C		3
DARPP-32^T75,S97,S130 + PP2C → DARPP-32^T75,S97,S130 - PP2C	7.5e + 06	12
DARPP-32^T75,S97,S130 - PP2C → DARPP-32^T75,S97 + PP2C		3
DARPP-32^{T34,T75,S97,S130} + PP2C → DARPP-32^{T34,T75,S97,S130} - PP2C	7.5e + 06	12
DARPP-32^{T34,T75,S97,S130} - PP2C → DARPP-32^T34,T75,S97 + PP2C		3