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. 2018 Jan 24;38(4):814–825. doi: 10.1523/JNEUROSCI.2276-17.2017

Figure 5.

Figure 5.

Dopamine maintains NSCs in an undifferentiated cycling state. a, Striatal content of dopamine in wild-type mice at 2, 12, and 24 months (m). b, MPTP experimental design. c, Immunoperoxidase detection of TH in coronal sections of SNpc (top) and the striatum (bottom) of mice chronically treated with saline or MPTP. d, Proportion of S100β+ among GFAP+ cells. e, Number of subependymal BrdU LRCs. f, Experimental design of the intranigral inoculation of LB and non-LB fractions. g, Immunofluorescent detection of S100β (red) and GFAP (green) in mice inoculated with NLB or LB fractions 4 months before death. White arrowheads point at double-positive cells. LV, Lateral ventricle. Proportion of S100β+ among GFAP+ cells. *p < 0.05 (Student's t test). ***p < 0.0001 (one-way ANOVA). Scale bar: g, 10 μm.