Figure 9.

Model for TMEM98 function in inhibiting MYRF self-cleavage and activity in the oligodendrocyte differentiation. A, Tmem98 is transiently expressed in newly differentiated oligodendrocytes. B, When expressed alone, N-fragments of MYRF are released from the ER membrane after self-cleavage and translocate into the nucleus to drive target-gene expression. C, When coexpressed with TMEM98, the release and nuclear translocation of MYRF N-fragments are suppressed, and the induction of target-gene expression by MYRF is turned off.