Figure 11.

Effects of apamin with and without AgTx on PPR. A, Repetitive firing of presynaptic (FSN1) and postsynaptic (FSN2) FSNs. B, C, Ten consecutive traces (gray) with averaged traces (black; B) and the scaled traces (C) in the control and during apamin application. D, Apamin had little effect on the PPR (n = 7). E, Repetitive firing of presynaptic (FSN3) and postsynaptic (FSN4) FSNs. Arrowheads indicate autaptic responses. F, Effects of apamin on uIPSCs in the presence of AgTx in the FSN3→FSN4 connection shown in E. G, Scaled traces in the control and during application of AgTx without and with apamin. Note the facilitative effect of apamin with AgTx on the PPR. H, uIPSC amplitude during AgTx and AgTx and apamin (n = 7). I, Apamin facilitated the PPR in the presence of AgTx (n = 7). *p < 0.05, paired t test.