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Unc18 in vesicle priming. A, Diagram representation of the proteins discussed. B, Tomosyn forms dead-end tomosyn-SNARE complex with syntaxin and SNAP25. C, Unc18 adopts two conformations. In a fusion incompetent state, furled Unc18 binds closed syntaxin. In the second conformation, unfurled Unc18 nucleates the assembly of the SNARE complex in a fusion competent state.
