Figure 3.

Disconnection of the prefrontostriatal projection prevents goal-directed learning. A, Summary of the experimental design. B, Summary of lesions in each group. C, Cresyl violet-stained sections (40 μm) showing a lesion of the PL (left), characterized by marked cell loss as outlined in left hemisphere; a CC lesion, indicated by tissue loss (middle); and a pDMS lesion, indicated by ventricle enlargement and structural shrinkage (right, right hemisphere). D, Distribution and location of the PL (left), CC (middle), and pDMS (right) lesions for all rats included in the analysis. E, Mean presses per minute averaged across each day of instrumental training for each group. F, Mean presses per minute on the valued and devalued lever averaged across the two tests for outcome devaluation under extinction. G, Mean presses per minute on the valued lever (gray bars) and devalued lever (red bars) during the first 2 min of Test 1 (left) and the last 2 min of Test 2 (right) of the extinction tests for devaluation. H, Mean presses per minute on the valued and devalued lever during the reinforced test for outcome devaluation. Error bars represent SEM, *p < 0.05.