Table 1.

Sepsis therapy, a catalog of failures.

Target	Strategy	References
Lps/Endotoxin	HA-1A	Ziegler et al., 1991
	E5531	Bunnell et al., 2000
	Anti-CD14	Reinhart et al., 2004
	Eritoran	Opal et al., 2013
	Polymyxin B	Payen et al., 2015
	conjugate
Endocrinopathy	Methylprednisolone	Bone et al., 1989
	Vasopressin	Ohsugi et al., 2016
Hypercoagulability /Disseminated Intravascular Coagulation (DIC)	Activated Protein C	Bernard et al., 2001
	Anti-thrombin	Warren et al., 2001
	Heparin	Zhang and Ma, 2006
	Thrombomodulin	Hagiwara et al., 2016
Cytokines	Anti-TNF-α	Tracey et al., 1987
	IL-1 receptor	Fisher et al., 1994
	Antagonists
	Soluble TNF-α receptor	Borrelli et al., 1996
	Diacerhein	Calisto et al., 2012
Eicosanoids	Ibuprofen	Bernard et al., 1997
Nitric Oxide	L-NMMA	Petros et al., 1994
Oxidat1ve Stress	Statins	Patel et al., 2012
	Selenium	Sakr et al., 2014
Nf-Kb Transcription	Curcumin	Zhong et al., 2016
Apoptosis	Caspase inhibitors	Weber et al., 2009

Most, if not all, were targeting inflammation including caspase inhibitors. Caspases do have a central role in inflammation (Mandal et al., 2018).