Table 7.
Protein analyses of selected VaC, ViF, KeF, and KFC proteins of A. baumannii for cellular localization, COG classification, antigenicity, and active site predictions.
| String-id | Protein description: function | Localization | COG analysis | Cleavage position | Epitope analysis | Active site analysis | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| PSORTb | Accession | Name | SignalP | LipoP | Peptide | Start | End | length | |||
| VaCAB | |||||||||||
| AB_01334 | Tetratricopeptide repeat protein: DNA binding | Unknown | COG5010 | TadD | 32,N | 31–32 | KHANDPQL | 547 | 554 | 8 | 511–523 |
| AB_02233 | Peptidase M16 inactive domain protein: metal ion binding; metalloendopeptidase activity | Outer Membrane | COG0612 | PqqL | 24,Y | 23–24 | KDKPKTLDQTDVKAEPLKDPKVY | 454 | 476 | 23 | 404–442 |
| ViFAB | |||||||||||
| AB_03351 | Thiol:disulfide interchange protein protein disulfide oxidoreductase activity | Periplasmic | COG1651 | DsbG | 23,Y | 22–23 | GKVEVP | 38 | 43 | 6 | 67–81 |
| QGEDGK | 184 | 189 | 6 | ||||||||
| AB_01731 | Nucleoside diphosphate kinase: ATP binding; metal ion binding; nucleoside diphosphate kinase activity | Extracellular | COG0105 | Ndk | 48,N | – | NAAHGSDSVAS | 114 | 124 | 11 | 104–128 |
| AB_02683 | Malate dehydrogenase: L-malate dehydrogenase activity | Unknown | COG0039 | Mdh | 28,N | – | GESLKDKINDPAW | 204 | 216 | 13 | 225–244 |
| AB_01948 | 50S ribosomal protein L7/L12: structural constituent of ribosome | Unknown | COG0222 | RplL | 51,N | – | APAGGAAAAAEEQSE | 42 | 56 | 15 | 38–50 |
| KeFAB | |||||||||||
| AB_03689 | DNA replication and repair protein RecF: ATP binding; single-stranded DNA binding | Cytoplasmic | COG1195 | RecF | 30,N | – | DPQSTDI | 114 | 120 | 7 | 112–165 |
| AB_03360 | Alkanesulfonate monooxygenase: alkanesulfonate monooxygenase activity | Cytoplasmic | COG2141 | COG2141 | 37,N | – | TWGEPPAAV | 198 | 206 | 9 | 140–172 |
| ALVGDPETV | 306 | 314 | 9 | 356–365 | |||||||
| AB_03276 | Bacterial sugar transferase: transferase activity, transferring glycosyl groups | Cytoplasmic Membrane | COG2148 | WcaJ | 30,N | – | FDAQGNPLPDEARI | 66 | 79 | 14 | 42–97 |
| AB_03274 | UDP-glucose 6-dehydrogenase: NAD binding; UDP-glucose 6-dehydrogenase activity | Cytoplasmic | COG1004 | Ugd | 17,N | – | KENTSSTHN | 307 | 315 | 9 | 306–399 |
| AB_03221 | Phosphopantetheine attachment domain protein: phosphopantetheine binding | Unknown | COG0236 | AcpP | 25,N | – | PETIDPDQKF | 24 | 33 | 10 | 32–67 |
| AB_03191 | ATP synthase F0, I subunit: hydrolase activity | Cytoplasmic Membrane | COG3312 | AtpI | 31,N | – | AR | 67 | 68 | 2 | 68–74 |
| AB_02008 | Uncharacterized protein | Unknown | COG2960 | COG2960 | 55,N | – | DEPKKD | 14 | 19 | 6 | 32–43 |
| AB_01991 | Response regulator receiver domain protein: DNA binding | Cytoplasmic | COG2197 | CitB | 26,N | – | SDTQQSPFDS | 139 | 148 | 10 | 131–174 |
| AB_01903 | Ribosome maturation factor RimP: Required for maturation of 30S ribosomal subunits | Cytoplasmic | COG0779 | COG0779 | 21,N | – | PVDENAEPVINEDGEVEQG | 46 | 64 | 19 | 60–61 |
| AB_01875 | DnaJ domain protein unfolded protein binding+C4 | Cytoplasmic | COG0484 | DnaJ | 62,N | – | GFGGGQQQYQRQ | 117 | 128 | 12 | 101–195 |
| AB_01854 | S-(Hydroxymethyl)glutathione synthase: carbon-sulfur lyase activity | Unknown | COG3791 | COG3791 | 46,N | – | TPLDQK | 104 | 109 | 6 | 72–115 |
| AB_01851 | 50S ribosomal protein L31 type B: structural constituent of ribosome | Cytoplasmic | COG0254 | RpmE | 20,N | – | QTKQTKEYQG | 30 | 39 | 10 | 40–41 |
| AB_01810 | Endonuclease/ exonuclease/ phosphatase family protein: endonuclease activity; exonuclease activity | Cytoplasmic | COG3021 | COG3021 | 23,N | – | PKPPSPTEAKDSTL | 208 | 221 | 14 | 245–291 |
| AB_01791 | 50S ribosomal protein L33: structural constituent of ribosome | Cytoplasmic | COG0267 | RpmG | 21,N | – | KNKRTM | 21 | 26 | 6 | 22–31 |
| AB_01758 | Sel1 repeat protein | Unknown | COG0790 | COG0790 | 21,Y | 20–21 | ASNGDNR | 120 | 126 | 7 | 97–129 |
| AB_01757 | Methionine biosynthesis protein MetW | Cytoplasmic | COG2226 | UbiE | 31,N | – | IK | 12 | 13 | 2 | 8–18 |
| NQ | 72 | 73 | 2 | 81–84 | |||||||
| AB_01723 | GTPase Der: GTP binding | Cytoplasmic Membrane | COG1160 | COG1160 | 31,N | – | SENPFEGRKSQVDERTA | 434 | 450 | 17 | 119–150 |
| AB_01691 | Uncharacterized protein | Unknown | NA | NA | 21,N | – | TMKPNNHSTETNTPPAI | 36 | 52 | 17 | 69–74 |
| AB_01682 | AP endonuclease, family 2: endonuclease activity; isomerase activity | Cytoplasmic | COG3622 | Hfi | 29,N | – | PGRHEPDTAQI | 211 | 221 | 11 | 206–242 |
| KFC | |||||||||||
| AB_02522 | Glutamate synthase [NADPH], large subunit: glutamate synthase (NADPH) activity | Cytoplasmic | COG0067 | GltB | 60,N | – | GRSNSGEGGEDPARY | 896 | 910 | 15 | 867–996 |
| COG0069 | GltB | ||||||||||
| COG0070 | GltB | ||||||||||
| AB_02769 | Putative fatty acid oxidation complex subunit alpha: 3-hydroxyacyl-CoA dehydrogenase activity; lyase activity | Cytoplasmic | COG1250 | FadB | 26,N | – | YKIPGGDPKTPA | 216 | 227 | 12 | 239–297 |
| AB_03233 | Methylmalonate-semialdehyde dehydrogenase (Acylating): methylmalonate-semialdehyde dehydrogenase (acylating) activity | Cytoplasmic | COG1012 | PutA | 70,N | – | GKTLADAEGD | 106 | 115 | 10 | 141–147 |
| AB_00091 | Methylmalonate-semialdehyde dehydrogenase (Acylating): methylmalonate-semialdehyde dehydrogenase (acylating) activity | Cytoplasmic | COG1012 | PutA | 44,N | – | ARKQPVYNPATGEIS | 41 | 55 | 15 | 140–145 |
| AB_03207 | GMP synthase [glutamine-hydrolyzing]: ATP binding; GMP synthase (glutamine-hydrolyzing) activity; pyrophosphatase activity | Cytoplasmic | COG0518 | GuaA | 23,N | – | GPESVHEEGSPRA | 61 | 73 | 13 | 60–92 |
| COG0519 | GuaA | ||||||||||
| AB_01641 | DNA polymerase I: 3′-5′ exonuclease activity; DNA binding; DNA-directed DNA polymerase activity | Cytoplasmic | COG0749 | PolA | 20,N | – | VKPAQTIETEDQASLTSQDDQLG | 303 | 325 | 23 | 599–687 |
| AB_03022 | Putative aminobutyraldehyde dehydrogenase: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | Cytoplasmic | COG1012 | PutA | 36,N | – | EVYAQSPNATEAEV | 32 | 45 | 14 | 33–97 |
| AB_02437 | Succinate-semialdehyde dehydrogenase [NAD(P)+]: succinate-semialdehyde dehydrogenase [NAD(P)+] activity | Cytoplasmic | COG1012 | PutA | 61,N | – | DGRQEGSTQGPLI | 318 | 330 | 13 | 330–386 |
| AB_01350 | Succinate-semialdehyde dehydrogenase [NAD(P)+]: succinate-semialdehyde dehydrogenase [NAD(P)+] activity | Cytoplasmic | COG1012 | PutA | 38,N | – | NATVPVSNPATGEEIG | 26 | 41 | 16 | 59–73 |
| AB_01047 | Succinate-semialdehyde dehydrogenase [NAD(P)+]: succinate-semialdehyde dehydrogenase [NAD(P)+] activity | Cytoplasmic | COG1012 | PutA | 16,N | – | GLGREGSKY | 459 | 467 | 9 | 410–476 |
| R6 | |||||||||||
| AB_00210 | Uncharacterized protein | Unknown | COG2911 | COG2911 | 21,N | – | VEQQPTSAPSSPK | 4 | 16 | 13 | |
| AB_00797 | Transcriptional regulator, TetR family: DNA binding | Cytoplasmic | COG1309 | AcrR | 39,N | – | EKA | 78 | 80 | 3 | |
| AB_03124 | Putative phage uncharacterized protein domain protein | Cytoplasmic Membrane | COG5412 | COG5412 | 40,N | – | DPTKPIEPPKPPKLGL GTAPPNPKLGIGTGE KDDKGGSKSSAKS KAEQEAKERQRQAEQ | 494 | 552 | 59 | 587–599 |
| AB_02872 | Uncharacterized protein | Cytoplasmic | NA | NA | 45,N | – | QQHAGESVKKNRKAQSIKS GYDESAEQSVELEED FEQYAAEQQQAR EQAKQQRQQQKREQAEQM | 122 | 185 | 64 | 65–89 |
| AB_02571 | Uncharacterized protein | Cytoplasmic | NA | NA | 42,N | – | SIDPEQVED | 118 | 126 | 9 | |
| QQAENPKKG | 294 | 302 | 9 | ||||||||
| AB_00406 | Uncharacterized protein | Cytoplasmic Membrane | NA | NA | 11,N | – | SGSARPGFS | 139 | 147 | 9 | 57–136 |
| AB_00641 | Uncharacterized protein | Cytoplasmic | NA | NA | 23,N | 17–18 | AEEKPTEKTEKTS TIKATEQPPKEEN | 22 | 47 | 26 | 16–97 |
| AB_01430 | CRISPR-associated protein, Csy2 family | Unknown | NA | NA | 32,N | – | RQAQDQENTAHA | 227 | 238 | 12 | 110–178 |
| AB_01223 | Transcriptional regulator, TetR family: DNA binding | Cytoplasmic | COG1309 | AcrR | 33,N | – | ESNQDDQ | 131 | 137 | 7 | |
| AB_01974 | Transcriptional regulator, TetR family: DNA binding | Cytoplasmic | COG1309 | AcrR | 11,N | – | EFPANSSERSSVKQ | 112 | 125 | 14 | |