Figure 6.

Antitumor activities of VCR liposome formulations on male BALB/c nude mice bearing human melanoma (NHEM) model. Therapeutic effects are shown as tumor volume change (A) and tumor growth inhibition (B). NHEM tumors were implanted in the dorsal flank of nude mice as described in Materials and methods. Once tumors were appropriately sized (∼250 mm³), mice were treated with VCR liposome formulations at a dose level of 2 mg/kg at day 1, day 5, and day 9. The control group was given 25 mL/kg saline solution i.v. on the same day. All mice began treatment on day 11 after tumor implantation. Tumor weight was recorded at day 14 post-administration. Data represented as mean ± SD (n=6). *p<0.05 as compared to control.