Table 2.
Pharmacokinetics parameters of VCR liposome formulations in rats
| PK parameters | GVM | SRLV-1 | SRLV-2 | SRLV-3 |
|---|---|---|---|---|
| AUC0-t (mg/L h) | 138.5±42.3 | 267.1±73.5 | 366.0±98.3 | 366.1±54.9 |
| AUC0-∞ (mg/L h) | 147.8±50.1 | 339.8±122.8 | 460. 5±194.5 | 463.2±56.1 |
| t1/2z (h) | 11.1±3.1 | 17.4±11.3 | 19.2±8.1 | 22.7±3.8 |
| Cmax (mg/L) | 26.5±3.2 | 25.4±5.1 | 28.5±4.6 | 25.8±2.4 |
| MRT0-t (h) | 9.8±2.1 | 13.0±3.1 | 16.0±1.4 | 16.5±0.4 |
| MRT0-∞ (h) | 12.8±4.0 | 24.6±11.4 | 29.6±8.8 | 30.9±3.3 |
Note: PK data in Wistar rats after a single dose of 1 mg/kg vincristine liposomes administered i.v. Data represented as mean ± SD (n=10).
Abbreviations: AUC0→t, area under the curve from 0 to tth hour; AUC0→∞, area under the curve during the whole time; t1/2z, half-life of elimination; Cmax, maximum concentration; MRT0→t, mean residue time from 0 to t; MRT0→∞, mean residue time from 0 to ∞.