Table 3.
Single dose and multi-dose toxicity studies of VCR liposome formulations in rats
| Dose | Formulations | Dead/treated | Day of death | |
|---|---|---|---|---|
| Single-dose | 3 mg/kg | GVM | 4/6 (67%) | 6, 6, 7, 8 |
| SRLV-1 | 3/6 (50%) | 6, 7, 10 | ||
| SRLV-2 | 0/6 (0) | / | ||
| SRLV-3 | 1/6 (17%) | 7 | ||
| 4 mg/kg | GVM | 6/6 (100%) | 4, 4, 5, 5, 6, 6 | |
| SRLV-1 | 6/6 (100%) | 5, 5, 6, 6, 6, 9 | ||
| SRLV-2 | 1/6 (17%) | 6 | ||
| SRLV-3 | 3/6 (50%) | 5, 6, 6 | ||
| 5 mg/kg | GVM | 6/6 (100%) | 2, 3, 3, 3, 4, 4 | |
| SRLV-1 | 6/6 (100%) | 3, 3, 4, 4, 4, 5 | ||
| SRLV-2 | 6/6 (100%) | 4, 5, 5, 5, 6, 7 | ||
| SRLV-3 | 6/6 (100%) | 3, 4, 4, 5, 5, 5 | ||
| Multi-dose | 1 mg/kg/day * 5 days | GVM | 10/10 (100%) | 4, 6, 7, 7, 7, 8, 8, 8, 8,10 |
| SRLV-1 | 10/10 (100%) | 8, 9, 10, 10, 11, 11, 11, 12, 12, 16 | ||
| SRLV-2 | 4/10 (40%) | 10,11,11,13 | ||
| SRLV-3 | 6/10 (60%) | 9, 9, 10, 11, 12, 14 |
Notes: The fraction is the proportion of animals per group dying within 14 days after last dose of a specified formulation at a given dose level. Percentage group mortality is in parentheses. Death were recorded from day 0 to 14 days after the last dose. The fraction is the proportion of animals per group dying within 14 days after last dose of a specified formulation at a given dose level. Percentage group mortality is in parentheses.