Table 2.
Analysis of salivary metabolite associations with obesity (second visit) for p ≤ 0.01 in predicting obesity (Mann-Whitney U-test).
| Biochemical | Super_Pathway | Sub_Pathway | p | AUC |
|---|---|---|---|---|
| INCREASE | ||||
| N1-Methyl-2-pyridone-5-carboxamide | Cofactors and Vitamins | Nicotinate and Nicotinamide Metabolism | 0.0003 | 0.72 |
| Urate | Nucleotide | Purine Metabolism, (Hypo)Xanthine/Inosine containing | 0.0005 | 0.71 |
| Sphingomyelin (d18:1/24:1, d18:2/24:0) | Lipid | Sphingolipid metabolism | 0.002 | 0.64 |
| Gamma-glutamylphenylalanine | Peptide | Gamma-glutamyl amino acid | 0.002 | 0.56 |
| Acisoga | Amino acid | Polyamine metabolism | 0.005 | 0.67 |
| Phosphate | Energy | Oxidative phosphorylation | 0.01 | 0.65 |
| Threonylphenylalanine | Peptide | Dipeptide | 0.01 | 0.65 |
| Acetylcarnitine | Lipid | Fatty acid metabolism(Acyl Carnitine) | 0.01 | 0.65 |
| Arginine | Amino acid | Urea cycle; Arginine and Proline metabolism | 0.01 | 0.65 |
| DECREASE | ||||
| 1-stearoyl-GPC (18:0) | Lipid | Lysolipid | 0.0002 | 0.73 |
| docosahexaenoate (DHA; 22:6n3) | Lipid | Polyunsaturated Fatty Acid (n3 and n6) | 0.001 | 0.69 |
| N-acetylglycine | Amino Acid | Glycine, Serine and Threonine Metabolism | 0.001 | 0.69 |
| 1-stearoyl-2-linoleoyl-GPC (18:0/18:2) | Lipid | Phospholipid Metabolism | 0.002 | 0.69 |
| 1-stearoyl-GPE (18:0) | Lipid | Lysolipid | 0.002 | 0.68 |
| 1-palmitoyl-2-arachidonoyl-GPC (16:0/20:4) | Lipid | Phospholipid Metabolism | 0.003 | 0.68 |
| oleoylcarnitine | Lipid | Fatty Acid Metabolism(Acyl Carnitine) | 0.003 | 0.64 |
| 2'-deoxyinosine | Nucleotide | Purine Metabolism, (Hypo)Xanthine/Inosine containing | 0.004 | 0.65 |
| cholesterol | Lipid | Sterol | 0.005 | 0.67 |
| 1-palmitoyl-2-oleoyl-GPC (16:0/18:1) | Lipid | Phospholipid Metabolism | 0.008 | 0.66 |
| isobutyrylcarnitine | Amino Acid | Leucine, Isoleucine and Valine Metabolism | 0.009 | 0.56 |
| 1-palmitoyl-2-linoleoyl-GPC (16:0/18:2) | Lipid | Phospholipid Metabolism | 0.009 | 0.66 |
| 1-palmitoyl-GPC (16:0) | Lipid | Lysolipid | 0.010 | 0.74 |
| arachidonate (20:4n6) | Lipid | Polyunsaturated Fatty Acid (n3 and n6) | 0.01 | 0.65 |
| sphingomyelin (d18:1/14:0, d16:1/16:0) | Lipid | Sphingolipid Metabolism | 0.01 | 0.60 |
| 1-(1-enyl-stearoyl)-2-linoleoyl-GPE (P-18:0/18:2) | Lipid | Plasmalogen | 0.01 | 0.58 |
The top ten biochemicals (upper panel) all increased in obese children. Sixteen biochemicals that significantly decreased in the saliva of obese children are listed in the lower panel.