Table 3.
Analysis of salivary metabolite associations with obesity (first visit) for p ≤ 0.01 in predicting obesity (Mann-Whitney U-test).
| Biochemical | Super_Pathway | Sub_Pathway | p | AUC |
|---|---|---|---|---|
| INCREASE | ||||
| Nicotinate ribonucleoside | Cofactors and Vitamins | Nicotinate and Nicotinamide Metabolism | 0.00007 | 0.73 |
| Xanthosine | Nucleotide | Purine Metabolism, (Hypo)Xanthine/Inosine containing | 0.004 | 0.67 |
| Phenol sulfate | Amino Acid | Phenylalanine and Tyrosine Metabolism | 0.004 | 0.67 |
| Phosphoenolpyruvate (PEP) | Carbohydrate | Glycolysis, Gluconeogenesis, and Pyruvate Metabolism | 0.006 | 0.66 |
| DECREASE | ||||
| Sulfate | Xenobiotics | Chemical | 0.001 | 0.70 |
| Caffeine | Xenobiotics | Xanthine metabolism | 0.005 | 0.55 |
| Ribitol | Carbohydrate | Pentose metabolism | 0.01 | 0.55 |
| Phenylacetate | Amino Acid | Phenylalanine and tyrosine metabolism | 0.01 | 0.65 |
| 4-hydroxyphenylacetate | Amino Acid | Phenylalanine and tyrosine metabolism | 0.01 | 0.65 |
The top four biochemicals (upper panel) all increased in obese children. Five biochemicals that significantly decreased in the saliva of obese children are listed in the lower panel.