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. 2019 Jun 20;10:1412. doi: 10.3389/fimmu.2019.01412

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Copyright © 2019 Fields, Günther and Sundberg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-18 sequestration by IL-18BP. (A) Crystal structure of IL-18 bound to IL-18BP (pdb 3F62). (B) Overlay of IL-18/IL-18BP crystal structure with ternary IL-18/IL-18Rα/IL-18Rβ to highlight IL-18BP resembling the D3 domain of IL-18Rα.