Table 2.
List of IL-1 family cytokine receptors with their respective nomenclatures, Uniprot IDs, alternative names, domains, and structures by PDB code.
| Receptor | Uniprot | Alternative name | Structure | Structure | Structure |
|---|---|---|---|---|---|
| PRIMARY RECEPTORS | |||||
| IL-1R1 | P14778 | IL-1RI, CD121a | 1ITB (with IL-1β) | 1G0Y (with antagonistic peptide) | 4DEP (IL-1β/IL-1RI/IL-1RAcP) |
| IL-1R2 | P27930 | IL-1RII, CD121b | 3O4O (IL-1β/IL-1RII/IL-1RAcP) | ||
| IL-1R4 | Q01638 | IL-33R, ST2, IL1-RL1, DER4, T1, IL-1R4 | 4KC3 (ST2/IL-33) | 5VI4 (ST2/IL-1RAcP/IL-33) | |
| IL-1R5 | Q13478 | IL-18Rα, IL-1Rrp, IL-1Rrp1 | 3WO4 (IL-18/IL-18Rα/IL-18Rβ) | 3WO3 (IL-18/IL-18Rα) | 4R6U (IL-18/IL-18Rα) |
| IL-1R6 | Q9HB29 | IL-36R, IL-1RL2, IL-1Rrp2, | |||
| CO-RECEPTORS | |||||
| IL-1R3 | Q9NPH3 | IL-1RAcP | 4DEP (IL-1β/IL-1RI/IL-1RAcP) | 3O4O (IL-1β/IL-1RII/IL-1RAcP) | |
| IL-1Rb | IL-1RAP | ||||
| IL-1R7 | O95256 | IL-18Rβ, AcPL | 3WO4 (IL-18/IL-18Rα/IL-18Rβ) | 3WO3 (IL-18/IL-18Rα) | 4R6U (IL-18/IL-18Rα) |
| IL-1R8 | Q6IA17 | SIGGIR, TIR8 | |||
| IL-1R9 | Q9NZN1 | IL-1RAPL1 OPHN4, TIGIRR-2 | 5WY8 (IL-1RAPL1/PTPRdelta 1T3G (TIR) | 4M92 (peptide 207-222 in complex with N33/Tusc3) | |
| IL-1R10 | Q9NP60 | IL-1RAPL2, TIGIRR-1 | |||