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. 2019 Jun 20;9:546. doi: 10.3389/fonc.2019.00546

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Copyright © 2019 Guo, Shen, Zhang, Moustafa, Ge and You.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-17A promotes migration of human cancer cells. Confluent monolayer of HeLa and DU-145 cells was scratched to make a wound and then treated without (control group) or with 20 ng/ml recombinant human IL-17A for the indicated time points. (A,C) Representative photomicrographs of the wounds; dotted lines mark the front edges of migrating cells; scale bar, 400 μm. (B,D) Wound healing rate was calculated as (wound width of time zero–that of each time point) ÷ wound width of time zero × 100%; data represent mean ± standard deviation (SD, error bars) of 3 independent experiments; ^*p < 0.05 between the IL-17A-treated group and the untreated control group.