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. 2019 Jun 20;13:647. doi: 10.3389/fnins.2019.00647

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Copyright © 2019 Opperhuizen, Foppen, Jonker, Wackers, van Faassen, van Weeghel, van Kerkhof, Fliers and Kalsbeek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of a Sham surgery on liver transcriptome and metabolome. (A) Heatmap of top 500 DEGs between Sham and Intact animals. A laparotomy caused a clearly distinct expression pattern even after 2 weeks of recovery. (B) Volcano Plot depicting the analysis of 78 metabolites in Sham-denervated and Intact-animals. The volcano plot shows a large number of metabolites with a divergent expression pattern due to the Sham surgery. Metabolites identified in red showed statistical significant changes of p < 0.05 (−log10 > 1.3) p < 0.01 (−log10 > 2) or p < 0.001 (−log10 > 3), metabolites in yellow showed a fold change > 2 (log2FC > 1).