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. 2019 May 20;10(6):1007–1017. doi: 10.1039/c9md00224c

Table 2. Inhibitory activities of selected compounds against DNA gyrase from S. aureus and topoisomerase IV from E. coli and S. aureus.

Compound	IC₅₀ ^a (μM) or RA ^b (%)
Compound	S. aureus DNA gyrase	E. coli topoisomerase IV	S. aureus topoisomerase IV
8 ^c	RA = 88	RA = 91	RA = 100
17	RA = 87	RA = 84	RA = 92
25	IC₅₀ = 63 ± 14	RA = 72	RA = 100
26	RA = 80	RA = 88	RA = 98
27	IC₅₀ = 11 ± 2	RA = 91	RA = 60
28	IC₅₀ = 1.4 ± 0.4	IC₅₀ = 11 ± 3	IC₅₀ = 14 ± 4
Novobiocin	IC₅₀ = 0.041 ± 0.007	IC₅₀ = 11 ± 2	IC₅₀ = 27 ± 7

^aConcentration of compound that inhibits the enzyme activity by 50%.

^bResidual activity of the enzyme at 10 μM concentration of the compound.

^cPreviously published results.20