Table 3.

Cross interactions between proinflammatory cytokines and metabolic hormones

	IL‐6	IL‐18	Adiponectin	HsCRP	Leptin	TWEAK	IGF1	TNF‐α	Insulin	FGF21
IL‐6 (pg/mL), r	1.000	0.275	0.016	0.467	0.193	−0.153	0.020	0.298	−0.083	−0.021
P value *		0.040	0.907	<0.001	0.155	0.261	0.884	0.026	0.541	0.923
IL‐18 (pg/mL), r	0.275	1.000	0.075	−0.023	0.183	−0.103	0.256	0.265	−0.019	0.339
P value	0.040		0.583	0.866	0.178	0.449	0.057	0.049	0.890	0.123
Adiponectin (μg/mL), r	0.016	0.075	1.000	0.048	−0.216	0.148	0.048	−0.149	−0.229	0.085
P value	0.907	0.583		0.727	0.110	0.276	0.726	0.274	0.090	0.707
HsCRP (mg/L), r	0.467	−0.023	0.048	1.000	−0.092	−0.089	−0.247	0.044	0.053	−0.191
P value	<0.001	0.866	0.727		0.501	0.513	0.066	0.748	0.697	0.395
Leptin (ng/mL), r	0.193	0.183	−0.216	−0.092	1.000	0.087	0.121	−0.072	0.214	0.139
P value	0.155	0.178	0.110	0.501		0.526	0.373	0.599	0.113	0.537
TWEAK (pg/mL), r	−0.153	−0.103	0.148	−0.089	0.087	1.000	0.155	−0.009	0.089	−0.021
P value	0.261	0.449	0.276	0.513	0.526		0.253	0.948	0.512	0.925
IGF1, ng/mL	0.020	0.256	0.048	−0.247	0.121	0.155	1.000	−0.046	0.133	0.186
P value	0.884	0.057	0.726	0.066	0.373	0.253		0.736	0.328	0.406
TNF‐α (pg/mL), r	0.298	0.265	−0.149	0.044	−0.072	−0.009	−0.046	1.000	−0.160	0.330
P value	0.026	0.049	0.274	0.748	0.599	0.948	0.736		0.238	0.134
Insulin (pmol/L), r	−0.083	−0.019	−0.229	0.053	0.214	0.089	0.133	−0.160	1.000	−0.311
P value	0.541	0.890	0.090	0.697	0.113	0.512	0.328	0.238		0.160
FGF21 (pg/mL), r	−0.021	0.339	0.085	−0.191	0.139	−0.021	0.186	0.330	−0.311	1.000
P value	0.923	0.123	0.707	0.395	0.537	0.925	0.406	0.134	0.160

FGF21, fibrolast growth factor 21; HsCRP, high‐sensitivity C‐reactive protein; IGF1, insulin‐like growth factor 1; IL, interleukin; TNF‐α, tumour necrosis factor α; TWEAK, tumour necrosis factor‐like weak inducer of apoptosis.

^* P value < 0.1 was considered to be statistically significant；Pearson's or Spearman's correlation r was performed using pre‐intervention measurements.