Table 4.
Changes in circulating factors after intensive lifestyle interventiona
| Parameter |
Pre‐intervention sarcopenic subjects (n = 32) Mean ± SD/M (P25, P75) |
Post‐intervention sarcopenic subjects (n = 32) Mean ± SD/M (P25, P75) |
P value * |
|---|---|---|---|
| IL‐6, pg/mL | 2.9 (2.0–5.9) | 2.8 (2.0–3.1) | 0.061 |
| IL‐18, pg/mL | 961.82 ± 884.72 | 492.87 ± 300.39 | 0.017 |
| TNF‐α, pg/mL | 34.43 ± 36.05 | 10.14 ± 4.80 | <0.001 |
| TWEAK, pg/mL | 1878.46 ± 554.24 | 1290.74 ± 455.49 | <0.001 |
| HsCRP, mg/L | 0.68 (0.32–1.49) | 0.78 (0.33–2.20) | 0.842 |
| Adiponectin, μg/mL | 2.43 (1.05–6.47) | 16.61 (7.11–25.67) | <0.001 |
| Leptin, ng/mL | 11.07 (5.65–30.25) | 12.37 (5.30–20.21) | 0.700 |
| IGF1, ng/mL | 62.17 ± 20.78 | 76.73 ± 32.54 | 0.075 |
| Insulin, pmol/L | 23.15 ± 18.20 | 80.47 ± 99.75 | <0.001 |
| FGF21, pg/mL | 49.99 (46.20, 57.05) | 53.80 (46.1, 59.3) | 0.610 |
HsCRP, high‐sensitivity C‐reactive protein; IGF1, insulin‐like growth factor 1; IL, interleukin; SD, standard deviation; M, median; Q1–3, 1st and 3rd quartile values; TNF‐α, tumour necrosis factor α; TWEAK, tumour necrosis factor‐like weak inducer of apoptosis.
a
Sarcopenic subjects accepted a 12 week intensive lifestyle intervention programme consisting of nutritional supplementation and resistance exercise.
*
P values calculated by paired‐sample Wilcoxon test.